Sperm dna testing fertility
DNA is the hereditary material in humans and other organisms and consists of two long chains—DNA strands—that are coiled around each other, each made of sugars and phosphate. Although all humans have the same bases, the order of these bases determines the information available for building and maintaining an organism. One major contributor to sperm DNA fragmentation is oxidative stress. Sperm DNA fragmentation also occurs when the body lacks the ability to repair breaks that occur in DNA, and when there is a deficiency of proteins that typically bind DNA and keep it in a compact form that is less susceptible to damage.
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The integrity of genetic material in the sperm is crucial for successful fertilisation and normal embryo development. Sperm DNA fragmentation is a term used to denote abnormal genetic material within the sperm, which in turn may lead to male subfertility , IVF failure and miscarriage. A conventional semen analysis done for sperm concentration, motility analysis and morphology assessment cannot assess the sperm at the molecular level and as result aid the detection of DNA fragmentation. In men, the major contributing factor for sperm DNA fragmentation is oxidative stress, which can be associated with one or more of the following:. It depends essentially on the cause. If the damage is caused by free radicals, a change in lifestyle and diet designed to protect against oxidative stress may help reduce the levels of DNA fragmentation.
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Your Exact sperm DNA test results provide important information about your reproductive health which can help you make informed decisions about lifestyle changes or treatments to improve your fertility. Exact tests measure sperm DNA damage which could be a significant factor affecting your fertility. The Exact test result shows three different indicators of DNA damage fragmentation compared against a fertile reference range. Most sperm from fertile men have low damage.
Semen analysis sperm concentration, motility and morphology is still used for routine male infertility assessment; however, these parameters have shown to be limited as surrogate markers of male fertility. Impaired sperm DNA integrity affects the sperm biological structure which may ultimately result in poor pregnancy outcomes [miscarriage, recurrent in vitro fertilization IVF failure] in couples with otherwise unexplained subfertility. However, the sperm biological structure cannot be determined with routine semen analysis. For this, specialized sperm function tests, including sperm DNA fragmentation SDF and reactive oxygen species, have been utilized 1.